The SciLifeLab Chemical Biology and Genome Engineering (CBGE) platform (https://www.scilifelab.se/servicearea/chemical-biology-and-genome-engineering/) aims to transform phenotypic observations into mechanistic insights through a multidisciplinary approach combining chemical, proteomic, and genetic technologies. The platform consists of three units: Chemical Biology Consortium Sweden (CBCS), CRISPR Functional Genomics (CFG), and Chemical Proteomics (ChemProt).

Scope of supported projects:

1. This call supports projects that have a clearly defined need for parallel services from more than one CBGE unit.

2. A major focus is to investigate the mechanism-of-action (MoA) and/or molecular targets of small molecules, for example compounds identified in phenotypic assays or other screening efforts. Projects focused on understanding mechanisms of existing drugs, or drug repositioning/repurposing, are equally suitable. Other therapeutic modalities beyond small molecules may also be considered.

3. We also welcome project types other than MoA studies that benefit from a multidisciplinary approach combining chemical biology, chemical proteomics, and functional genomics. Examples include (but are not limited to): Functional characterization of genetic perturbations, development of chemical tools or probes, investigations of cellular pathways relevant to health and disease, etc.

⚠️ Mandatory feasibility discussion: A feasibility discussion with CBGE must be scheduled well in advance, no later than November 14, 2025. To arrange this meeting, please contact Michaela Vallin (Project Coordinator) – michaela.vallin@ki.se

The complete call text is available below. The application word template available in Anubis/below must be used. Finalized project proposals are uploaded directly as a single pdf file into Anubis. All submissions are treated as confidential and will only be shared with a limited group of CBGE personnel for evaluation under strict confidentiality.